COMPOSÉ LIGAND DE HSP70, UTILISATION, COMPOSITION PHARMACEUTIQUE ANTITUMORALE, CONSTRUCTION GÉNÉTIQUE POUR L'EXPRESSION D'UN LIGAND DE HSP70, PROCÉDÉ DE PRODUCTION, PROCÉDÉ D'ÉVALUATION DE CELLULES TUMORALES, MÉTHODE DE SENSIBILISATION DE CELLULES TUMORALES, MÉTHODE DE SENSIBILISATION DE CELLULES TUMORALES À DES AGENTS CHIMIOTHÉRAPEUTIQUES
UNIÃO BRASILEIRA DE EDUCAÇAO E ASSISTÊNCIA- MANTENEDORA DA PUCRS
发明人:
CAZABUENA BONORINO, CRISTINA BEATRIZ,DUARTE DE SOUZA, ANA PAULA
申请号：
EP13867908
公开号：
EP2940040A4
申请日:
2013.12.27
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The present invention provides the use of HspBP1 protein or part thereof for the preparation of an anti-tumor pharmaceutical composition, and its optional combination with one or more chemotherapeutic agents. Also disclosed are: a gene construct for the expression of said binder； a production process； a process of evaluation of tumor cells； and a method of sensitization of tumors to chemotherapeutic agents. The invention also provides a new experimental model in vivo and in vitro for the development/evaluation of anti-tumor agents. The pharmaceutical compositions of the invention provide anti-tumor action and have high specificity to neoplastic cells, resulting in less cytotoxicity to normal dividing cells. These and other advantages of the invention are characterized as a solution to the drawbacks of currently known chemotherapy therapeutic regimens.
