FORMES AMELIOREES D'UN INHIBITEUR SELECTIF DE LA PI3K DELTA UTILISEES DANS DES PREPARATIONS PHARMACEUTIQUES

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专利权人:

RHIZEN PHARMACEUTICALS SA

发明人:

VAKKALANKA, SWAROOP KUMAR VENKATA SATYA

申请号：

CA2949932

公开号：

CA2949932A1

申请日:

2015.05.26

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

The present invention relates to solid state forms of a p-toluenesulfonic acid salt (PTSA) of the selective PI3K delta inhibitor (S)-2-(1-(4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-(3-fluorophenyl)-4H- chromen-4-one (TGR-1202). The present invention also relates to methods of preparing the same, pharmaceutical compositions containing them, and methods of treating a PI3K kinase mediated disease or disorder, such as cancer, by administering the same.

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