Hazel Joan Dyke,Lewis Gazzard,Karen Williams,Huifen Chen,Samuel Kintz,Joy Drobnick,Joseph P. Lyssikatos,Simon Goodacre,Calum Macleod,Charles Ellwood
申请号：
US14743835
公开号：
US09440976B2
申请日:
2015.06.18
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention relates to 1,7-diazacarbazole compounds of Formula (I), (I-a) and (I-b) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chk1) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
