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Il-1beta Antibody for Human
专利权人:
NOVARTIS AG
发明人:
GRAM HERMANN,PADOVA FRANCO E DI
申请号:
NO20030827
公开号:
NO332609B1
申请日:
2003.02.21
申请国别(地区):
NO
年份:
2012
代理人:
摘要:
Refers to a Molecule 1 u00df Link (Antibody) Antibody with Antigen binding site includes (1) a variable domain of immunoglobulin heavy chain (VH) comprising the RGions hypervariable CDR1 (i) Val Tyr Gly met ASN), (ii) CDR2 (Ile ile TRP Tyr Gly ASP ASP ASN GLN Tyr Tyr ala - ASP ser Lys Gly Val)(iii) CDr3 - Arg - Leu ASP THR Gly Pro); 2) an immunoglobulin light chain variable domain (VL) comprising hypervariable sequences (i) CDR1 (Arg - ala GLN GLN be be be be be ile Gly leu- HIS), (ii) CDR2 '(ala GLN PHE be be be), (iii) CDr3' (HIS - Gln - - - Be - Leu - prop; also refers to DNA encoding Heavy or light chains or Fragments of same.It also relates to a process for the production. The Antibody may be useful for the treatment of Osteoporosis and osteoarthritisEt IL-ip-bindende molekyl, nærmere bestemt et antistoff til human IL-1β, spesielt et humant antistoff til human IL-1β er tilveiebrakt, hvor CDR av de tunge og lette kjedene har aminosyresekvenser som definert, for anvendelse i behandlingen av en IL-1 -formidlet sykdom eller forstyrrelse, som f.eks. osteoartritt, osteoporose og andre inflammatoriske artrittyper.
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