TAM, TIM,N&apos,ZEMBA, BLAISE,LEUNG-TOUNG, REGIS,WANG, YINGSHENG,ZHAO, YANQING,YU, LILY
申请号：
PE2012000979
公开号：
PE20121642A1
申请日:
2007.12.14
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
A pharmaceutically acceptable d-isopropylendosulfan-d-triptopheno formula salt (I),(II) and (III),Whether it's Capricorn or crystal For formula (I),M is potassium or lithium, where 2-theta values are 9.91, 14.84, 15.81, 18.97, 19.76, 24.04, 24.36, 24.82, 25.48, 27.49, 27.94, 28.42, 30.82, 31.28, 31.69, 32.17, 34.35, 35.81 and 36.96 X-ray powder derivatives, and they are 13.71, 15.71 lithium salts. 20.11, 23.34, 24.1, 25.09, 27.31, 27.72, 28.39, 29.31, 30.19, 31.21, 32.06, 33.05, 33.62 and 37.41. For formula (II),B is calcium or magnesium, and the peak value of magnesium crystal salt is 12.2, 13.74, 14.84, 16.16, 17.96, 18.52, 18.94, 19.49, 21.05, 21.56, 22.56, 23.36, 24.12, 26.27, 27.65, 28.42, 29.14, 30.55, 31.77, 32.62, 33.26, 35.05, 36.34, 37.22 and 38.05. For formula (III),A is tert butilamonio, tris (hydroxymethyl) methylammonium or n-methyl-d-glucosamine. There's also a preparation process and a drug synthesisREFERIDA A UNA SAL FARMACEUTICAMENTE ACEPTABLE DE D-ISOGLUTAMIL-D-TRIPTOFANO DE FORMULAS (I), (II) Y (III), EN SUS FORMAS AMORFAS O CRISTALINAS. PARA LA FORMULA (I), M ES POTASIO O LITIO, DONDE PARA LA SAL CRISTALINA DE POTASIO SE PRESENTA UN PATRON DE DIFRACCION DE RAYOS X EN POLVO PARA VALORES 2-THETA DE 9,91, 14,84, 15,81, 18,97, 19,76, 24,04, 24,36, 24,82, 25,48, 27,49, 27,94, 28,42, 30,82, 31,28, 31,69, 32,17, 34,35, 35,81 Y 36,96, Y PÀRA LA SAL CRISTALINA DE LITIO PRESENTA PICOS DE 13,57, 15,53, 18,71, 20,11, 23,34, 24,1, 25,09, 27,31, 27,72, 28,39, 29,31, 30,19, 31,21, 32,06, 33,05, 33,62 Y 37,41. PARA LA FORMULA (II), B ES CALCIO O MAGNESIO, DONDE PARA LA SAL CRISTALINA DE MAGNESIO PRESENTA PICOS DE 12,2, 13,74, 14,84, 16,16, 17,96, 18,52, 18,94, 19,49, 21,05, 21,56, 22,56, 23,36, 24,12, 26,27, 27,65, 28,42, 29,14, 30,55, 31,77, 32,62, 33,26, 35,05, 36,34, 37,22 Y 38,05. PARA LA FORMULA (III), A ES TERT-BUTILAMONIO, TRIS(HIDROXIMETIL)METILAMONIO O N-METIL-D-GLUCOSILAMONIO. TAMBIEN ESTA REFERIDA A UN PROCESO DE PREPARACION Y A UNA COMPOSICION FARMA
