use of a compound with ep4 antagonistic activity or a pharmaceutically acceptable salt thereof, use of a compound of formula (i), (ii), (iii), (iv), (va) or (vb), or a salt pharmaceutically acceptable drug thereof, pharmaceutical composition and method for treating il-23 mediated diseases in an animal subject, including a mammalian subject
use of a compound with ep4 antagonistic activity or a pharmaceutically acceptable salt thereof, use of a compound of formula (i), (ii), (iii), (iv), (va) or (vb), or a salt pharmaceutically acceptable thereof, pharmaceutical composition and method for treating il-23 mediated diseases in an animal subject, including a mammalian subject. This invention relates to a compound with ep4 antagonist activity, or a pharmaceutically acceptable salt thereof with ep4 receptor antagonist activities, which is useful in the treatment of immune disease or allergy. The present invention also relates to a compound of formula (i), (ii), (iii), (iv), (va) or (vb), or a pharmaceutically acceptable salt thereof with ep4 receptor antagonist activities. which is helpful in treating immune disease or allergy. The present invention also relates to a pharmaceutical composition for the treatment of immune disease or allergy comprising a therapeutically effective amount of a compound of formula (i), (ii), (iii), (iv), (va) or ( vb), or a pharmaceutically acceptable salt thereof. further, this invention relates to a method for treating immune disease or allergy in an animal subject, including a mammalian subject, comprising administering to the animal subject, including a mammalian subject, a compound of formula (i), (ii ), (iii), (iv), (va) or (vb), or a pharmaceutically acceptable salt thereof.uso de um composto com atividade antagonística de ep4 ou um sal farmaceuticamente aceitável do mesmo, uso de um composto da fórmula (i), (ii), (iii), (iv), (va) ou (vb), ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica e método para o tratamento de doenças mediadas por il-23 em um sujeito animal, incluindo um sujeito mamífero. esta invenção refere-se a um composto com atividade antagonista de ep4, ou um sal farmaceuticamente aceitável do mesmo com atividades antagonistas de receptor ep4, que é útil no tratamento de doença imune ou alergia. a presente invenção também se refere a um
