CHEN, Xi,DRAGOLI, Dean R.,FAN, Pingchen,JAEN, Juan C.,LI, Yandong,POWERS, Jay P.,MALATHONG, Viengkham,PUNNA, Sreenivas,TANAKA, Hiroko,ZHANG, Penglie
申请号：
ES13866291
公开号：
ES2648994T3
申请日:
2013.12.20
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound represented by the structure (Ib2): ** Formula ** in which each A is independently selected from the group consisting of N and CH； A1 is N or C (R5)； A2 is N or C (R7)； R1 is Cl or F； R3 is selected from the group consisting of C1-8 alkyl, C1-8 haloalkyl, C1-8 hydroxyalkyl, in which the alkyl portions of R3 are further optionally substituted by 1-3 Ra； R5, R7 and R8 are each independently selected from the group consisting of H, halogen, CN, C1-8 alkyl, C3-8 cycloalkyl, C2-8 alkenyl, C2-8 alkynyl, C1-8 haloalkyl, C1- hydroxyalkyl 8, -ORa, -CO2Ra, -NRaRb, -CONRaRb, aryl, 5- or 6-membered heteroaryl and 3, 4-, 5 or 6-membered heterocycloalkane in which the heteroatoms present as the ring vertices of the heteroaryl rings and heterocycloalkane are selected from N, O and S, and in which the alkyl, cycloalkyl, aryl, heteroaryl and heterocycloalkane portions of R5, R7 and R8 are further optionally substituted by 1-3 Ra； and each Ra and Rb is independently selected from the group consisting of hydrogen, hydroxyl, halogen, cyano, C1-8 alkyl, C1-8 alkoxy, C1-8 haloalkyl, C3-6 cycloalkyl, C3-6 cycloalkylalkyl, amino, alkylamino C1-8, C1-8 dialkylamino, carboxamide, carboxy C1-4 alkyl ester, carboxylic acid, and -SO2-C1-8 alkyl, or a pharmaceutically acceptable salt, hydrate, solvate, rotamer or N-oxide thereof.Un compuesto representado mediante la estructura (Ib2): **Fórmula** en la que cada A se selecciona independientemente entre el grupo que consiste en N y CH； A1 es N o C(R5)； A2 es N o C(R7)； R1 es Cl o F； R3 se selecciona entre el grupo que consiste en alquilo C1-8, haloalquilo C1-8, hidroxialquilo C1-8, en la que las porciones alquilo de R3 están además opcionalmente sustituidas por 1-3 Ra； R5, R7 y R8 cada uno se selecciona independientemente entre el grupo que consiste en H, halógeno, CN, alquilo C1-8, cicloalquilo C3-8, alquenilo C2-8, alquinilo C2-8, haloalquilo C1-8, hidroxialquilo C1-8, -ORa, -CO2Ra, -NRaRb, -CONRaRb, arilo, heteroarilo de 5 o 6 miembro
