RESEARCH COOPERATION FOUNDATION OF YEUNGNAM UNIVERSITY;영남대학교 산학협력단
发明人:
CHOI, In Ho,최인호,LEE, Eun Ju,이은주
申请号：
KRKR2017/013190
公开号：
WO2018/135738A1
申请日:
2017.11.20
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
The present invention relates to a composition for inhibiting myostatin activity, containing a matrix gla protein as an active ingredient. More specifically, it is confirmed that a composition containing a matrix gla protein as an active ingredient promotes the differentiation of muscle satellite cells by increasing the expression of genes associated with the differentiation of the muscle and inhibits myostatin activity by inhibiting the binding of myostatin, which induces muscle wasting, with ACVRIIB, and thus the composition containing a matrix gla protein as an active ingredient can be effectively usable as an agent for modulating myostatin activity and an agent for treating muscle diseases such as myostatin-induced muscle wasting.La présente invention concerne une composition pour inhiber l'activité de la myostatine, contenant une protéine gla matricielle en tant que substance active. Plus spécifiquement, il est confirmé qu'une composition contenant une protéine gla matricielle en tant que substance active stimule la différenciation de cellules satellites musculaires par augmentation de l'expression de gènes associés à la différenciation du muscle et inhibe l'activité de la myostatine par inhibition de la liaison de myostatine, qui induit une atrophie musculaire, avec ACVRIIB, et par conséquent, la composition contenant une protéine gla matricielle en tant que substance active peut être efficacement utilisable en tant qu'agent pour moduler l'activité de la myostatine et un agent pour traiter des maladies musculaires telles que l'atrophie musculaire induite par la myostatine.본 발명은 매트릭스 gla 단백질을 유효성분으로 함유하는 미오스타틴 활성 저해용 조성물에 관한 것으로, 보다 상세하게는 매트릭스 gla 단백질을 유효성분으로 함유하는 조성물은 근육분화와 관련된 유전자들의 발현을 증가시켜 근육위성세포의 분화를 촉진하고 근육감소를 유도하는 미오스타틴와 ACVRIIB의 결합을 저해시켜 미오스타틴의 활성을 억제시키는 것으로 확인됨에 따라, 상기 매트릭스 gla 단백질을 유효성분으로 함유하는 조성물은 미오스타틴 활성 조절제 및 미오스타틴에 의해 유도되는 근육감소와 같은 근육질환 치료제로 효과적으로 사용될 수 있다.
