BALDERES PAUL J.,EASTMAN SCOTT W.,ERICKSON HANS K.,LUDWIG DALE L.,MOXHAM CHRISTOPHER M.,PLOWMAN GREGORY D.,RIGBY ALAN C.
申请号：
CL2016001496
公开号：
CL2016001496A1
申请日:
2016.06.15
申请国别(地区):
CL
年份:
2017
代理人:
摘要：
The invention provides conjugates that consist of a drug moiety agent and a cell binding agent that target human fibroblast growth factor receptor 3 (FGFR3). These conjugates have therapeutic use as they are designed and tailored to target a specific cell population and deliver a powerful cytotoxin inside the cell. The conjugate of the present invention has significant advantages over other conjugates known in the art by providing a targeted tumor therapy as well as bystander activity to neighboring cells in an important oncology receptor that is only moderately expressed.COMPUESTOS AL RECEPTOR-3 DEL FACTOR DE CRECIMIENTO DEL FIBROBLASTO (FGFR3) Y MÉTODOS DE TRATAMIENTO.
