MAMMEN, MATHAI,DUNHAM, SARAH,HUGHES, ADAM,LEE, TAE WEON,HUSFELD, CRAIG,STANGELAND, ERIC,CHEN, YAN
申请号:
CA2515777
公开号:
CA2515777C
申请日:
2004.02.13
申请国别(地区):
CA
年份:
2013
代理人:
摘要:
This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3,R4, R5, R6, R7, W, a, b and c are as defined in the specification, or apharmaceutically acceptable salt or solvate or stereoisomer thereof. Thebiphenyl derivatives of this invention possess both .beta.2 adrenergicreceptor agonist and muscarinic receptor antagonist activity and therefore,such biphenyl derivatives are useful for treating pulmonary disorders, such aschronic obstructive pulmonary disease and asthma.