A cartridge (3) and a nebulizer (1) for nebulizing a fluid (2) as well as a method for fluidically connecting the cartridge to the nebulizer are proposed. The cartridge comprises a closure (21) with a valve (29), wherein the valve displaces fluid into the nebulizer when opened. Further, the cartridge forms two axially spaced sealings (S5, S6) with the nebulizer when connected.