Douglas Richman,Mary T Wrin,Susan Little,Christos J. Petropoulos,Neil T. Parkin,Jeannette Whitcomb,Wei Huang
申请号：
US14926837
公开号：
US09841425B2
申请日:
2015.10.29
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Provided are methods for identifying whether a compound inhibits entry of a virus into a cell. The method may include obtaining nucleic acid encoding a viral envelope protein from a patient infected by the virus and co-transfecting it into a first cell along with a viral expression vector which lacks a nucleic acid encoding the envelope protein. The method may further include contacting the viral particles produced by the first cell with a second cell to which the virus binds in the absence and presence of the compound and measuring the amount of signal produced by the second cell.
