Katalin Varadi,Peter Turecek,Brigitte Keil,Sylvia Peyrer-Heimstaett,Hans-Peter Schwarz
申请号：
US14261608
公开号：
US20140232029A1
申请日:
2014.04.25
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The invention provides a kit for measuring the thrombin generation in a sample of a patient's blood or plasma, or in a sample of clotting factors. The kit contains lyophilized tissue factor/phospholipid-complex and a lyophilized mixture containing a thrombin-substrate and CaCl2. The invention also provides processes for preparing the reagents for the kit. The kit can be used in a method for measuring the thrombin generation in a sample, wherein it is possible to detect changes in thrombin generation kinetics, for example after administration of inhibitor bypassing agents to a patient who has developed inhibitors to an exogenous clotting factor such as Factor VIII.
