The invention relates in particular to a solid sustained-release formulation for parenteral administration comprising:a) triptorelinacetate, and b) one or more excipients comprising a lactic acid and/or glycolic acid polymer or copolymer or a mixture of lactic acid and/or glycolic acid polymers and/or copolymers, said fonnulation coniaining 10 to 99 % triptorelin acetate by weight relative to the total weight of the fonnulation and being obtained by a process comprising the melting of the mixture of triptorelin acetate and excipient or excipients during the melting-extrusion of the triptorelin acetate with the excipient or excipients, said formulation being such that it releases the triptorelin acetate over a period ofat least one week once administered to a patient by parenteral route.本發明特別係關於一種非腸胃道投與用之固體持續釋放調配物,其包含:a)曲普瑞林醋酸鹽,及b)一或多種賦形劑,其含有乳酸及/或羥乙酸聚合物或共聚物或乳酸及/或羥乙酸聚合物及/或共聚物之混合物,該調配物含有10至99重量%之曲普瑞林醋酸鹽,相對於調配物之總重量,及經含有曲普瑞林醋酸鹽及賦形劑或賦形劑類之混合物於曲普瑞林醋酸鹽與賦形劑或賦形劑類之熔化-擠壓時曲普瑞林醋酸鹽與賦形劑或賦形劑類之混合物之熔化方法而獲得,一旦經非腸胃道途徑投與該調配物於病患後會以超過至少一週之期間釋放曲普瑞林醋酸鹽。
