The invention pertains to a method for eluting a radionuclide-label or a radionuclide-labeled compound using a solid phase extraction resin, to a device for performing such a method, and to a computer program for controlling such a device. Specifically, the method according to the invention enables the automated synthesis of a radionuclide-labeled compound using anion exchange resin or a reversed phase resin, and comprises the step of removing or eluting a radionuclide-label (f luorine-18, etc.) that is bound to an anion exchange resin, or a radionuclide-labeled compound that is bound to a reversed phase resin, by performing a pulsed elution with an eluent.Linvention concerne un procédé pour élution de marqueur radionuclide ou de composé marqué par radionuclide utilisant une résine dextraction en phase solide, un dispositif permettant de réaliser un tel procédé et un programme informatique permettant de contrôler un tel dispositif.