Young Woo Park,Ki Won Jo,Kyu Won Cho,Ji Hyun Park,Soon Sil Hyun,Yun Jung Park
申请号：
US14002600
公开号：
US09617304B2
申请日:
2012.03.02
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention relates to a novel endocytic motif, and in particular, to a fusion polypeptide including the motif represented by an amino acid sequence of SEQ ID NO. 1 and a protein transduction domain, a pharmaceutical composition for preventing or treating cancer including the same, and a method for treating cancer including the step of administering the composition. The present invention shows the effects of suppressing metastasis, infiltration, angiogenesis, and growth of cancer by specifically inhibiting c-Met endocytosis and effectively inhibiting HGF/c-Met signaling pathway associated with metastasis and growth of various types of cancer cells. Therefore, the present invention can be applied to an anticancer agent for various types of cancer.
