SORBONNE UNIVERSITÉ;INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人:
Xavier Nicol,Oriol Ros Torres
申请号：
US16759703
公开号：
US20200299653A1
申请日:
2018.11.02
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The disclosure pertains to the field of molecular means capable of binding to, and preferably of chelating, cGMP, appropriate for use in vitro or in vivo and preferably capable of targeting specific cellular compartments. The polypeptides of the disclosure comprise a chimeric construction derived from the N terminus part of PKG-Iα and PKG-Iβ, and the two cGMP binding sites of the wild type PKG.
