EVALUATION OF NEUROPROTECTIVE EFFECT OF ETHANOLIC EXTRACT OF BOSWELLIA SERRATA OLEO GUM RESIN ON HALOPERIDOL INDUCED PARKINSON`S DISEASE IN SWISS ALBINO MICE

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专利权人:

发明人:

DONDAPATI SUBBA REDDY,NEMALIKANTI ASHA,NUKABATHINI AMANI,TANGA NAGA VARA LAKSHMI,VUTUKURI SWATHI,CHATLA SUPRIYA,KATTUPALLI SOWJANYA,SANKULA KAMESWARA RAO

申请号：

IN201841035223

公开号：

IN201841035223A

申请日:

2018.09.19

申请国别(地区):

IN

年份:

2018

代理人:

摘要：

Parkinson?s is a clinical syndrome characterized by rigidity, tremors, bradykinasia and improper gait. The present study evaluated the neuroprotective effect of ethanolic extract of Boswellia serrata oleo gum resin on haloperidol induced Parkinson?s disease in Swiss albino mice. Animals were divided into 6 groups 5 animals each for the study. Ethanolic extract of Boswellia serrata oleo gum resin 500mg/kg when give orally has shown better result when compared to that of carbidopa treated group. Catalepsy activity, Actophotometer method, wire hanging test, grip strength test, vertical pole test, FST were determined for the screening Neuroprotective effect of this plant extract. Boswellia serrata oleo gum resin 500mg/kg has reduced the free radical levels also by showing positive effect in SOD, MDA, GSH.

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