Williams, Spencer John,Stapleton, David,Zammit, Steven,Kelly, Darren James,Gilbert, Richard Ernest,Krum, Henry
申请号：
ES14173039
公开号：
ES2689484T3
申请日:
2007.07.05
申请国别(地区):
ES
年份:
2018
代理人:
摘要：
A compound of Formula 2: ** Formula ** for use in the treatment of focal segmental glomerulosclerosis； wherein R1 and R2, 20 which may be the same or different, are selected from the group consisting of a C1 to C10 alkyl, C3 to C10 cycloalkyl, C3 to C10 cycloalkylmethyl, C3 to C10 alkene, C3 to C10 alkyne and a chain that contains a heterocyclic or fused ring, any of which may be optionally substituted； X1 and X2 are the same or different and are selected from the group consisting of a bond, O, N and S； T is a single or double bond； R3 is selected from the group consisting of H, C3 to C10 alkene, C3 to C10 alkyne and a chain containing a heterocyclic or fused ring, any of which may be optionally substituted； R4 is selected from the group consisting of H, OH, OR6, NHR6 and NR6R7； R5 is selected from the group consisting of H, NHR6, NR6R7, OR, halogen, C3 to C10 alkene, C3 to C10 alkyne and a chain consisting of a heterocyclic or fused ring, any of which may be optionally substituted； R6 and R7, which may be the same or different, are selected from the group consisting of H, C1 to C10 alkyl, C3 to C10 cycloalkyl, C3 to C10 cycloalkylmethyl, C3 to C10 alkene, C3 to C10 alkyne, aryl, C5 to C20 alkaryl, and a hydrocarbon chain containing a heterocyclic or fused ring, any of which may be optionally substituted； R8 is selected from the group consisting of H, C1 to C10 alkyl, C3 to C10 cycloalkyl, C3 to C10 cycloalkylmethyl, C3 to C10 alkene, C3 to C10 alkyne, aryl, C5 to C20 alkaryl and a hydrocarbon chain containing a heterocycle or fused ring, any of which may be optionally substituted； and n is an integer between 0 and 4； or pharmaceutically acceptable salts thereof； with the proviso that when X1 and X2 are both O or a bond, and one of R1 or R2 is a C1 to C4 alkyl, the other of R1 or R2 is a C4 to C10 alkyl, C3 to C10 cycloalkyl, C3 to C10 cycloalkylmethyl, C3 to C10 alkyne, or a chain containing a heterocyclic or fused ring； and with the proviso that the compound is no
