Provide the antibody or antigen-binding fragment of anti-c-Met, and anti-C-met antibodies-cytotoxic drug conjugate, the antibody or antigen-binding fragment are chimeric antibody or humanized antibody, it additionally provides comprising the anti-C-met antibodies of humanization, antigen-binding fragment, the pharmaceutical composition of antibody-cell drug toxicity conjugate or its officinal salt or solvated compounds can use what treating cancer.提供了抗c‑Met的抗體或抗原結合片段，及抗c‑Met抗體‑細胞毒性藥物偶聯物，所述抗體或抗原結合片段爲嵌合抗體或人源化抗體，還提供了包含人源化抗c‑Met抗體、抗原結合片段，抗體‑細胞毒性藥物偶聯物或其可藥用鹽或溶劑化合物的藥物組合物，可用於治療癌症。
