The present invention relates to glyco-CF2-serine and glyco-CF2-threonine compounds of formula (I) having a difluro-, substituted alkyl-carbonyl moiety: or a pharmaceutically acceptable salt thereof, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportion, in particular a mixture of enantiomers, and particularly a racemate mixture, as well as to their process of preparation, their use in the peptide synthesis, said peptide and the use of said peptides, such as in the preservation of biological materials, cells, tissues, organs and in cosmetics.