An arrangement includes a housing, a plurality of sampling and analysis site contained within the housing, each of the sampling and analysis sites having a skin- penetration member having a first end configured to pierce the skin, and an inner lumen in communication with the first end, an actuator constructed and arranged to drive the skin penetration member, an analyte quantification member in fluid communication with the inner lumen of the skin-penetration member, and a seal configured to protect the skin-penetration member, actuator, and analyte quantification member from contamination. Integrated devices including such arrangements are also described.
