The present invention provides a composition that can treat cancer by specifically acting on anti-transmembrane protein 180 (TMEM-180), a test method for cancer that includes a step for measuring TMEM-180 in a sample, and an antibody used in the composition and the method.本發明提供特異地作用於抗-跨膜蛋白(transmembrane protein)180(TMEM-180)而可治療癌之組成物,以及提高包含測定試料中之TMEM-180之步驟的癌之檢查方法,以及其所使用之抗體。