Embodiments described herein provide improved systems and methods for corneal pachymetry. These systems and methods can be used to improve the accuracy of corneal measurements that are used for a wide variety of different ophthalmic procedures. One embodiment provides a system and method for corneal pachymetry using a plenoptic detector. For example, a corneal pachymetry system can comprise a light source, a plenoptic detector and a processing system coupled to the plenoptic detector. The light source is configured to illuminate the cornea of the eye, and the plenoptic detector is positioned at an angle relative to the eye. The plenoptic detector is configured to receive an image of the light source reflected from the cornea and generate plenoptic image data representing the images. The processing system is coupled to the plenoptic detector and is configured to analyze the plenoptic image data to accurately determine the corneal thickness of the eye.