GOSUDARSTVENNOE UCHREZHDENIE SANKT-PETERBURGSKIJ NAUCHNO-ISSLEDOVATELSKIJ INSTITUT SKOROJ POMOSHCHI IM. I.I. DZHANELIDZE
发明人:
GOTE SERGEJ VLADIMIROVICH,Готье Сергей Владимирович (RU),BAGNENKO SERGEJ FEDOROVICH,Багненко Сергей Федорович (RU),MOJSJUK JAN GENNADEVICH,Мойсюк Ян Геннадьевич (RU),REZNIK OLEG NIKOLAEVICH,Резник Оле
申请号：
RU2010126694/14
公开号：
RU0002441608C1
申请日:
2010.06.29
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
FIELD: medicine.SUBSTANCE: invention is referred to the area of medicine, namely to transplantology and can be used for restoration and maintenance of vitality of an ischemically damaged donor organ. Before explantation of organ from donor body for 2-3 hours the normothermic perfusion of abdominal blood supply regions is performed using pulsating flow of oxygen enriched perfusate on the basis of blood, from which the activated leucocytes and underoxidized products of biochemical decay are removed additionally. The explantation of organ out of donors body is performed. The normothermic perfusion of isolated organ is performed. During the organ perfusion process the estimation of its viability for transplantation is performed. The initial systolic pressure is established as 35 mm Hg in case of optimal implant state, 40-45 mm Hg for implants with borderline ischemic damage. Then the estimation is performed for degree of opening of circulatory bed of an organ by alteration of resistive index value. If within the period of 4-6 hours the resistive index does not increase or decrease the organ is presumed not viable for transplantation. If within this time the value of resistive index decreases by 2-3 fold and the flow speed is established within 80-150 ml/min the perfusion is continued till the moment of donor organ transplantation.EFFECT: restoration of vitality of donor organs with borderline characteristics clear estimation of its viability for transplantation and long-time maintenance of functional state of a transplantation viable organ.1 dwg, 2 dwg, 2 exИзобретение относится к медицине, а именно к трансплантологии, и предназначено для восстановления и поддержания жизнеспособности ишемически поврежденного донорского органа. Перед эксплантацией органа из тела донора в течение 2-3 часов проводят нормотермическую перфузию абдоминального региона кровоснабжения пульсирующим потоком обогащенного кислородом перфузата на основе крови, из которого дополнительно удаляют активи
