The present invention relates to method for producing hypo-metallated redox-active metallothionein (MT) proteins, pharmaceutical compositions containing the proteins, and uses the pharmaceutical compositions for treatment of conditions originating from elevated intracellular oxidative stress and/or dis-balanced intracellular redox-potential and/or redox-potential-dependent imbalance of metal ions.本發明係關於製造具有氧化還原活性之低金屬化金屬硫蛋白的方法、含有該蛋白的醫藥組合物,以及應用該醫藥組合物來治療因為升高的細胞內氧化壓力及/或失衡的細胞內氧化還原電位及/或氧化還原依賴型的金屬離子失衡所引起的疾病。
