BUNDOCK PAUL,DE BOTH MICHIEL THEODOOR JAN,HOGERS RENE CORNELIS JOSEPHUS,WACHOWSKI LUDVIK KEVIN
申请号：
US20060158149
公开号：
US2010186124(A1)
申请日:
2006.12.21
申请国别(地区):
美国
年份:
2010
代理人:
摘要：
A method and oligonucleotides for targeted nucleotide exchange of a duplex DNA sequence, wherein the donor oligonucleotide contains at least one modified nucleotide which is a LNA having a higher binding affinity compared to naturally occurring A, C, T or G and/or binds stronger to a nucleotide in an opposite position in the first DNA sequence as compared to a naturally occurring nucleotide complementary to the nucleotide in the opposite position in the first DNA sequence.
