A method of repairing a heart valve provides intravascular access for repairof a heart valvethrough a ventricular trans-septal approach. An external guide catheter can beinsertedthrough a vein of a patient into the right ventricle via the right atrium. Aninternal guidecatheter can be inserted through the external guide and can provide access tothe septumfor a puncture tool to create an opening through the septum to the leftventricle. The internalguide can then be advanced into the left ventricle and used to guide adeployment catheterthat deploys a repair device onto the heart valve.
