The present invention concerns a control system (1) for a micro-motor for dental or surgical use comprising a control box (10) provided with an adjustment knob (2), mounted in a way rotatable about a rotational axis (A-A). The adjustment knob (2) is made up of a control support (20) integral with an encoder (3) integrated in the said box (10), and a sterilizable button (21) coupled in a removable way to the said control support (20).