FELDHAUS, ANDREW L.,费德豪斯 安德列Ｌ,費德豪斯 安德列Ｌ,GARCIA-MARTINEZ, LEON F.,贾西亚 马帝兹 李奥Ｆ,賈西亞 馬帝茲 李奧Ｆ,DUTZAR, BENJAMIN H.,杜萨 班杰明Ｈ,杜薩 班傑明Ｈ,ALLISON, DANIEL S.,艾利森 丹尼尔Ｓ,艾利森 丹尼爾Ｓ,ANDERSON, KATIE OLSON,安德生 凯蒂Ｏ,安德生 凱蒂Ｏ,费德豪斯 安德列L,費德豪斯 安德列L,贾西亚 马帝兹 李奥F,賈西亞 馬帝茲 李奧F,杜萨 班杰明H,杜薩 班傑明H,艾利森 丹尼尔S,艾利森 丹尼爾S,安德生 凯蒂O,安德生 凱蒂O
申请号：
TW104142772
公开号：
TW201629098A
申请日:
2015.12.18
申请国别(地区):
TW
年份:
2016
代理人:
摘要：
The present invention is directed to antibodies and fragments thereof having binding specificity for ACTH. Embodiments of this invention relate to the binding fragments of antibodies described herein, comprising the sequences of the VH, VL and/or CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates anti-ACTH antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention further contemplates methods of making said anti-ACTH antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-ACTH antibodies and binding fragments thereof for the diagnosis, assessment, prevention and treatment of diseases and disorders associated with ACTH, such as CAH, FGD, Cushing’s Disease, Cushing’s Syndrome, Parkinson’s disease, obesity, diabetes, sleep disorders, depression, anxiety disorders, cancer, muscle atrophy, hypertension, hyperinsulinemia, cognitive dysfunction, Alzheimer’s disease, galactorrhea, stress related conditions, cardiac conditions, metabolic syndrome, hyperaldosteronism, Conn's syndrome and familial hyperaldosteronism.本發明係針對對於ACTH具有結合特异性之抗體及其片段。本發明之實施例係關於本文所述之抗體之結合片段，包含本文所述之VH、VL及/或CDR多肽之序列，及編碼其之多核苷酸。本發明亦涵蓋結合至一或多個官能性或可偵測部分之抗ACTH抗體及其結合片段。本發明進一步涵蓋製備該等抗ACTH抗體及其結合片段之方法。本發明之實施例亦關於抗ACTH抗體及其結合片段之用途，其用於診斷、評估、預防及治療與ACTH相關之疾病及病症，諸如CAH、FGD、庫興氏病(Cushing's Disease)、庫興氏症候群(Cushing's Syndrome)、帕金森氏病(Parkinson's disease)、肥胖、糖尿病、睡眠障礙、抑鬱症、焦慮症、癌症、肌肉萎縮、高血壓、血胰島素增多症、認知功能障礙、阿茲海默氏病(Alzheimer's disease)、乳溢症、應激相關病狀、心臟病狀、代謝症候群、醛固酮增多症、康氏症候群(Conn's syndrome)及家族性醛固酮增多症。
