A method of operating an analyte measurement device is described. The device has a display, a user interface, a processor, a memory and a number of user interface buttons. An analyte is measured with the analyte measurement device and a value representative of the analyte is displayed. The user is prompted to activate a test reminder and the test reminder is activated to remind the user to conduct a test measurement at a different time. To activate a lest reminder, the user presses one of the user interface buttons to turn the analyte measurement device on, and in response to a prompt to confirm the selection of a test reminder, presses one of the user interface buttons to confirm selection of the test reminder. The prompting may comprise repetitively flashing on the display an icon representative of one of the user interface buttons, or illuminating one of the user interface buttons, to prompt a selection of such user interface button.