Antonio Alcami Alcami Pertejo,Ali Alejo Herberg,Maria Begona Ruiz-Arguello,Yin Ho,Margarida Saraiva,Vincent P. Smith
申请号：
US11661633
公开号：
US08759485B2
申请日:
2005.09.02
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Chemokine binding activity of viral TNF receptors and related proteins. The invention relates to a C-terminal domain (CTD) of viral tumor necrosis factor receptors (vTNFRs) CrmB or CrmD or CTD homologues (CTD1, CTD2 and CTD3) from poxvirus and their functional homologues, including derivatives, and fragments, for use in binding chemokines and their analogues and/or to enhance the immunomodulatory properties of TNFRs or in blocking binding of chemokines to their corresponding cell surface receptors and/or to modulate chemokine biological activity.
