PURPOSE: A therapeutic composition is provided to be able to be effectively used in prevention, alleviation or treatment of kidney diseases as the Panax species plant extract or the product of the Maillard type browning reaction with glucose amino acid have an excellent removal ability of active oxygen, and remarkably excellent activation to suppress damage of kidney epithelial cell due to the oxidative stress. CONSTITUTION: A pharmaceutical composition for prevention or treatment of kidney diseases comprises ginsenoside Re, Panax species plant extract including ginsenoside Re, or the product of the Maillard browning reaction obtained by reacting ginsenoside-originated saccharide with amino acid at 100-130deg.C, as an active ingredient. A composition for health functional food for prevention or alleviation of kidney diseases includes ginsenoside Re, Panax species plant extract including ginsenoside Re, or the product of the Maillard browning reaction obtained by reacting ginsenoside-originated saccharide with amino acid at 100-130deg.C, as an active ingredient. The Panax species plant is Korean ginseng, Panax quinquefolius, Panax notoginseng, Japanse seng, Panax trifolium, Himalayan ginseng, Panax vietnamensis, their cultured root, or their combination. [Reference numerals] (AA) Ginsenoside Re； (BB) Ginsenoside Rg_2； (CC) Dehydration reaction； (DD) Ginsenoside Rg_6； (EE) Ginsenoside F_4； (FF) Separated glucose + Glycine； (GG) Maillard browning reaction본 발명은 진세노사이드 Re, 진세노사이드 Re를 포함하는 파낙스속 식물 추출물, 또는 글루코스를 아미노산과 함께 100 ~ 130℃에서 0.5 ~ 12 시간 반응시켜 얻어진 마이얄형 갈색화 반응 생성물을 유효성분으로 포함하는 신장질환의 예방, 개선 또는 치료용 조성물을 제공한다.
