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5-HT receptor modulators and their methods of use
专利权人:
AbbVie Inc.;AbbVie Deutschland GmbH & Co KG
发明人:
Wang, Ying,Brewer, Jason,Akritopoulou-Zanze, Irini,Djuric, Stevan,Pohlki, Frauke,Braje, Wilfried,Relo, Ana-Lucia
申请号:
ES12175535
公开号:
ES2568262T3
申请日:
2010.04.22
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
A compound of formula (I): ** Formula ** or a pharmaceutically acceptable salt thereof, wherein R1, R2, R4, R5 and R6 are independently selected from the group consisting of hydrogen, alkenyl, alkyl, haloalkyl, G1 and - (CR4aR5a) m-G1; R4a and R5a, each time they appear, are each independently hydrogen, halogen, alkyl or haloalkyl; G1, each time it appears, is independently aryl or heteroaryl, wherein each G1 is independently substituted or unsubstituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of alkyl, alkenyl, alkynyl, halogen, cyano, -G3, -NO2, -OR1b, -O- (CR4bR5b) m-G3, -OC (O) R1b, -OC (O) N (Rb) (R3b), -SR1b, - S (O) R2b , -S (O) 2R2b, -S (O) 2N (Rb) (R3b), -C (O) R1b, -C (O) OR1b, -C (O) N (Rb) (R3b), -C (OH) [(CR4bR5b) m-R4b] 2, -N (Rb) (R3b), - N (Ra) C (O) R1b, -N (Ra) C (O) O (R1b), -N ( Ra) C (O) N (Rb) (R3b), - (CR4bR5b) m-G3, - (CR4bR5b) m-NO2, - (CR4bR5b) m-OR1b, - (CR4bR5b) m-OC (O) R1b, - (CR4bR5b) m-OC (O) N (Rb) (R3b), - (CR4bR5b) m-SR1b, - (CR4bR5b) mS (O) 2R2b, - (CR4bR5b) m- S (O) 2N (Rb) (R3b), - (CR4bR5b) mC (O) R1b, - (CR4bR5b) mC (O) OR1b, - (CR4bR5b) mC (O) N (Rb) (R3b), - (CR4bR5b) mN (Rb) (R3b ), - (CR4bR5b) mN (Ra) C (O) R1b, - (CR4bR5b) mN (Ra) C (O) O (R1b), - (CR4bR5b) mN (Ra) C (O) N (Rb) ( R3b), cyanoalkyl, and haloalkyl; Ra and Rb, each time they appear, are each independently hydrogen, alkyl or haloalkyl; R1b and R3b, each time they appear, are each independently hydrogen, alkyl or haloalkyl; R2b, each time it appears, is independently alkyl or haloalkyl; R4b and R5b, each time they appear, are each independently hydrogen, halogen, alkyl or haloalkyl; m, each time it appears, is independently 1, 2, 3, 4 or 5; G3, each time it appears, is independently aryl or heteroaryl, wherein each G3 is independently substituted or unsubstituted with 1, 2, 3, 4 or 5 substituents selected from the group consisting of alkyl, alkenyl, alkynyl, halogen, cyano, -NO2, -OR1b, -OC (O) R1b, -OC (O) N (Rb) (R3b), -SR1b, -S (
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