CD33 specific chimeric antigen receptors for cancer immunotherapy

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专利权人:

CELLECTIS

发明人:

Roman Galetto

申请号：

US15301686

公开号：

US09944702B2

申请日:

2015.04.02

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present invention relates to Chimeric Antigen Receptors (CAR) that are recombinant chimeric proteins able to redirect immune cell specificity and reactivity toward selected membrane antigens, and more particularly in which extracellular ligand binding is a scFV derived from a CD33 monoclonal antibody, conferring specific immunity against CD33 positive cells. The engineered immune cells endowed with such CARs are particularly suited for treating lymphomas and leukemia.

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