The present invention relates to a new class of compounds of the general Formula (i): wherein R 1 is selected from the group consisting of: a substituted or unsubstituted C 1 -C 10 alkyl group and a polar atom selected from the group consisting of: oxygen, nitrogen, sulfur or halogen atom R 2 and R 3 are polar groups chosen from the group consisting of: =O, =NH, -NH 2 , -OH, =S, -X 1 wherein X 1 is a halogen atom and isomers thereof, which can in particular be used as inhibitors of Proline Racemase, as a medicament and as a component of a pharmaceutical composition. Also disclosed are in silico methods to determine inhibitors of a target using a novel structural progression approach.
