Université Catholique de Louvain;Université de Liège
发明人:
申请号：
EP14151665.8
公开号：
EP2896400A1
申请日:
2014.01.17
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
The present invention relates to a compound comprising one or more PEG moieties having a molecular weight of more than 12 kDa, wherein said compound is a therapeutic agent active for treating a respiratory disease. The present invention also relates to the use of a PEGylated therapeutic agent for treating a respiratory disease. Another object of the invention is a method for enhancing the bioavailability of a therapeutic agent, for enhancing the pulmonary residency of a therapeutic agent and/or for reducing the pulmonary clearance of a therapeutic agent, wherein said methods comprise the PEGylation of the therapeutic agent. In a preferred embodiment the respiratory disease is cystic fibrosis and the therapeutic agent dornase alpha or an anti-IL13 antibody.
