The United States of America;as represented by the Secretary;Department of Health and Human Services
发明人:
Hisataka Kobayashi,Peter Choyke
申请号：
US16695674
公开号：
US20200095331A1
申请日:
2019.11.26
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present disclosure relates to compositions and methods of killing cells in vitro or in vivo. In particular examples, the method includes contacting a cell having a cell surface protein with a therapeutically effective amount of an antibody-IR700 molecule, wherein the antibody specifically binds to the cell surface protein. In particular examples the antibody recognizes a tumor-specific antigen on the surface of a tumor cell. The cell is subsequently irradiated, such as at a wavelength of 660 to 740 nm at a dose of at least 1 J cm−；2, thereby killing the cell. Also provided are wearable devices that include an article of clothing, jewelry, or covering； and an NIR LED incorporated into the article, which can be used with the disclosed methods.
