Derrick Ryan Witcher,Donmienne Doen Mun Leung,Joseph Vincent Manetta,Peng Luan,Ying Tang
申请号：
BRPI0922288
公开号：
BRPI0922288A2
申请日:
2009.12.01
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the level of serum iron, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a subject in vivo.
