ALCALDE-PAIS, María de las Ermitas,DIAZ-FERNANDEZ, José-Luís,MESQUIDA-ESTEVEZ, María,PALOMA-ROMEU, Laura
申请号：
ES13732996
公开号：
ES2607183T3
申请日:
2013.07.04
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of general formula (I): ** Formula ** in which Ra and Rb independently represent a 5- or 6-membered aryl radical optionally substituted with a halogen or a branched or unbranched, saturated or unsaturated C1-6 alkyl radical ； a 5 or 6 membered heteroaryl radical having at least one heteroatom selected from N, O or S as a ring member, optionally substituted with a halogen or a branched or unbranched, saturated or unsaturated C1-6 alkyl radical； or the following moiety: ** Formula ** with the proviso that one of Ra and Rb represents this moiety and the other represents an aryl radical of 5 or 6 members optionally substituted with a halogen or a C1-6 alkyl radical branched or not branched, saturated； or a 5 or 6 membered heteroaryl radical having at least one heteroatom selected from N, O or S as a ring member, optionally substituted with a halogen or a branched or unbranched C1-6 alkyl radical, saturated A is a C or OR； B is a C or N； R1 and R2 independently represent an H, or R1 and R2 together with the bridge-forming N form a 5- to 7-membered heterocyclic ring that may have at least one additional heteroatom selected from N, O or S and that may be optionally substituted with a branched or unbranched, saturated or unsaturated C1-6 alkyl radical or with an aryl radical optionally substituted with a C1-6 alkyl group, a halogen or an OH group； n is 0, 1 or 2； m is 0, 1, 2, 3 or 4； with the proviso that when A is O, m is different from 0； and with the proviso that when B represents a C and Rb represents a halogen substituted phenyl, Ra cannot represent the remainder: ** Formula ** with R1 and R2 together with the N to which they are attached forming a piperazine, or a pharmaceutically acceptable salt, enantiomer or geometric / diastereomeric or solvate isomer thereof.Un compuesto de fórmula general (I):**Fórmula** en la que Ra y Rb representan independientemente un radical arilo de 5 o 6 miembros opcionalmente sustituido con un halógeno o un radical alquilo C1
