The present invention describes combination treatment comprising a PD-1 axis binding antagonist and a MEK inhibitor and methods for use thereof, including methods of treating conditions where enhanced immunogenicity is desired such as increasing tumor immunogenicity for the treatment of cancer.本発明は、PD-1軸結合アンタゴニストとMEK阻害剤を含む併用療法と、癌の治療のための腫瘍免疫原性の増大のような免疫原性の増大が所望される症状を治療する方法を含むその使用方法を記述する。