Mucosal vascular addressins and uses thereof

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专利权人:

Michael J. Briskin

发明人:

Michael J. Briskin

申请号：

US11732400

公开号：

US08277808B2

申请日:

2007.04.03

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The present invention relates to isolated antibodies and antigen-binding fragments thereof that bind naturally occurring human MAdCAM, wherein said naturally occurring human MAdCAM comprises a polypeptide with at least 90% sequence identity to SEQ ID NO:2 or SEQ ID NO:4, said naturally occurring human MAdCAM binds α4β7, and wherein said isolated antibodies and antigen-binding fragments thereof inhibit binding of said naturally occurring human MAdCAM to human α4β7, and wherein said antibody inhibits adhesion of RPMI 8866 cells to cells that express said human MAdCAM.

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