The present application refers to a disposable apparatus for topical application of a therapeutic agent, comprising: a breakable vial (100) comprising a handle section (122) and a vial section (102), wherein the breakable vial is completely separable into the handle section and the vial section in response to a manually applied separation force. The vial section (102) comprises a void (104) dimensioned to contain a unit dose of a sterile therapeutic topical agent. The apparatus further comprises an elongated member comprising a proximal portion supported by the handle section (124) and a distal portion provided with a sterile applicator element, at least the applicator element completely enclosed within the vial section with the applicator element immersed within the therapeutic topical agent, and a hermetic seal (129) between the handle section (122) and vial section (102), wherein complete separation of the handle section (122) and the vial section (102) exposes the elongated member and the applicator element for topical application of the therapeutic agent saturating the applicator element. According to the invention, the void (104) is sterile, the hermetic seal (129) maintains sterility of at least the vial section (102) prior to handle section (122) and vial section (102) separation, the therapeutic topical agent comprises a prostaglandin analog, and the applicator element comprises a brush having a generally tapered shape that serves to trap the therapeutic topical agent using capillary action.使い捨て式滅菌易破壊性バイアルは、手動で適用される分離力に応答して完全に分離可能である、ハンドル区画とバイアル区画とを含む。バイアル区画は、単位用量の滅菌局所治療用薬剤を収容するように寸法決めされた滅菌空間を含む。伸長部材は、ハンドル区画によって支持される近位部分と、ブラシ等の滅菌塗布器要素が提供される遠位部分とを備える。少なくとも塗布器要素がバイアル区画内に完全に封入され、塗布器要素は局所治療用薬剤に浸漬している。ハンドル区画とバイアル区画との間の密封性封止は、ハンドル区画とバイアル区画との分離の前に、少なくともバイアル区画の滅菌状態を維持する。ハンドル区画とバイアル区画との完全な分離によって、塗布器要素を飽和している治療用薬剤の局所適用のために、伸長部材および塗布器要素が露出する。【選択図】図１Ａおよび図１Ｂ
