A device for clearing obstructions from a medical tube, such as a chest tube, is disclosed in various embodiments. The device features a shuttle member that is magnetically coupled to a guide wire within a guide tube, through the guide-tube wall, so that translation of the shuttle member induces a corresponding translation of the guide wire within the guide tube, without penetrating or compromising the guide-tube wall. In this manner, when the guide tube is coupled to a medical tube where obstructions have formed, the guide wire and clearance member may be inserted into and withdrawn from the medical tube, via actuation of the shuttle member, to engage and help clear such obstructions from the medical tube without compromising the sterile field. Methods of clearing a medical tube of obstructions are also disclosed.