A composition for preventing, ameliorating or treating fibrosis or non-alcoholic steatohepatitis containing a novel compound and its active ingredient.
PROBLEM TO BE SOLVED: To provide a composition for preventing, improving or treating fibrosis or non-alcoholic steatohepatitis, which contains a novel compound and the active ingredient thereof. The present invention relates to a novel compound and a composition for preventing, ameliorating or treating fibrosis or non-alcoholic steatosis containing the novel compound as an active ingredient, and more particularly, preventing, ameliorating or ameliorating fibrosis. The present invention relates to a novel compound of Chemical Formula 1 having an excellent therapeutic effect and a composition for preventing, ameliorating or treating fibrosis or non-alcoholic steatosis containing the compound as an active ingredient. The novel compound of the present invention effectively regulates the expression of snail and vimentin, which are regulators of epithelial-mesenchymal transition (EMT), and regulates the activation of EMT, thereby effectively treating fibrosis. Can be prevented, ameliorated or treated. Moreover, the novel compound of the present invention has excellent pharmacokinetic properties, enables rapid delivery of the drug into the body even by oral administration, can exert a stable effect in the body, and can be used safely without major side effects. be able to. Since the novel compound of the present invention can effectively block fibrosis of hepatocytes, non-alcoholic steatohepatitis can also be effectively improved or treated. [Selection diagram] Fig. 1【課題】 新規化合物及びそれを有効成分として含有する、線維症または非アルコール性脂肪肝炎の予防、改善または治療用組成物を提供する。【解決手段】 本発明は、新規化合物及びそれを有効成分として含有する、線維症または非アルコール性脂肪肝炎の予防、改善または治療用組成物に係り、さらに詳しくは、線維症の予防、改善または治療効果に優れた化学式１の新規化合物及びそれを有効成分として含有する、線維症または非アルコール性脂肪肝炎の予防、改善または治療用組成物に関する。本発明の新規化合物は、上皮間葉移行（Ｅｐｉｔｈｅｌｉａｌ Ｍｅｓｅｎｃｈｙｍａｌ Ｔｒａｎｓｉｔｉｏｎ、ＥＭＴ）の調節因子であるｓｎａｉｌおよびｖｉｍｅｎｔｉｎの発現を効果的に調節してＥＭＴの活性化を調節し、これにより線維症を効果的に予防、改善または治療することができる。しかも、本発明の新規化合物は、薬物動態特性も非常に優れて経口投与でも体内へ薬物の迅速な送達を可能にし、体内で安定した効果を発揮することができ、大きな副作用がなく安全に使うことができる。なお、本発明の新規化合物は、肝細胞の線維化を効果的に遮断することができるので、非アルコール性脂肪肝炎も効果的
