600603 Disclosed herein is a compound of formula (I), wherein the variables are defined in the specification, and the use thereof in the treatment of neurological or psychiatric disorders. Addtionally disclosed is a product compising said compound and a mGluR5 orthosteric agonist for use in the treatment of neurological or psychiatric disorders. Specific embodiments of the compound include: 5,6-dihydro-2-(phenylethynyl)-7(4H)-benzothiazolone, 2-[(5-fluoro-3-pyridinyl)ethynyl]-5,6-dihydro-7(4H)-benzothiazolone, 2-(4-methyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl)-5,6-dihydro-1,3-benzothiazol-7(4H)-one, and 6,7-dihydro-5-(2-methoxyethyl)-2-(phenylethynyl)-thiazolo[5,4-c]pyridin-4(5H)one.
