This bill, the alteration kurosutorijiumu toxin, discloses the polynucleotide numerator which the constituent and the said alteration kurosutorijiumu toxin which include installed die protease disconnection region join domain the code is done, and the constituent which includes two these chain configurations of the said alteration kurosutorijiumu toxin.本明細書は、改変クロストリジウム毒素、組込型プロテアーゼ切断部位結合ドメインを含む組成物、該改変クロストリジウム毒素をコードするポリヌクレオチド分子、及び、該改変クロストリジウム毒素の二本鎖形態を含む組成物を開示する。