Process of manufacturing of self-standing films having a variable and controlled thickness, characterized by a controlled though-porosity micro-pattern made of natural or synthetic, pH-dependent, polyelectrolyte macro-molecules, the process comprising:a) cathodic and/or anodic electrochemical/electrophoretic deposition of said natural or synthetic macromolecules, on a working electrode in the form of micro-patterned conductive template, having suitable size/dimensions of the lumen of the meshes, a working electrode immersed in an electrolyte solution comprising said macromolecules；b) mechanical removal of the self-standing films having variable and controlled thickness characterized by a controlled through-porosity micro-pattern obtained in step a) from the working electrode.
