PYRIMIDINE DERIVATIVES AS ZAP-70 INHIBITORS

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专利权人:

Nigel Ramsden

发明人:

Nigel Ramsden,Jeremy Major,Adeline Morel,Mihiro Sunose,Nelly Piton

申请号：

US13377550

公开号：

US20120142667A1

申请日:

2010.06.10

申请国别(地区):

US

年份:

2012

代理人:

摘要：

The invention relates to compounds of formula (I)wherein R1 to R5, X and X1 to X3 have the meaning as cited in the description and the claims. Said compounds are useful as inhibitors of ZAP-70 for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.

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