The present invention relates to novel microgranule preparations. More particularly, the present invention is to provide microgranule preparations for oral medication that is mixed with inactivity core coated with a medicine layer and sugar or sugar alcohol. The sugar or the sugar alcohol includes xylitol.COPYRIGHT KIPO 2014[Reference numerals] (AA) Very severe(BB) Degree for the feeling of irritation(CC) Experimental example 1: evaluating the feeling of irritation(DD) Yes(EE) Little(FF) Almost none(GG) None(HH) Example 1-6(II) Comparative example 1-6(JJ) Comparative example 7-12(KK) Comparative example 13-18약물층으로 코팅된 불활성 코어와 당 또는 당 알코올을 혼합한 것을 특징으로 하는 경구투여용 마이크로그래뉼 제형이 제공된다.
